PhD in computational Biochemistry

The Martin Luther University Halle-Wittenberg, Faculty of Natural Sciences I, Institute of Pharmacy, has a vacancy for a fixed term position for 3 and half years at the earliest possible date as a

PhD Student (m-w-d)

to be filled as part-time (50 %).

Remuneration will be paid up to pay group E13 TV-L, depending on the tasks assigned and fulfilment of the personal requirements.

The position is a part of a joint project between the Institute of pharmacy at MLU and computational chemistry group at Leibniz Institute of Plant Biochemistry (IPB-Halle). The PhD position will be placed mostly at the computational chemistry group at IPB Halle (AG Davari).

• Preparation of enzyme data from public databases and transcriptomic data
• Development of machine learning (ML) architectures for the prediction of functions and enzyme-substrate pairs
• In silico enzyme mining
• Prediction of the recombination landscape of enzyme variants by ML models
• Enzyme characterization and preparation of protein mutants
• Possibility to get a doctoral degree is given

• Diploma or Master's degree in computational biology, bioinformatics, cheminformatics, computational (bio)chemistry or biophysics or a comparable field
• Profound knowledge in one of the following areas: Programming language (Python, C/C++), machine learning and deep learning methods (PyTorch, TensorFlow), knowledge management and databases, computational biochemistry or biophysics
• Experience in state-of-the-art machine learning methods (deep learning, active learning and reinforcement learning)
• Previous experience in cheminformatics would be an advantage, but is not a prerequisite.
• Knowledge of biochemical and enzymological methods, e.g. enzyme characterization and protein mutations, is an advantage
• Creative, curious, team-oriented and enthusiastic personality

Applications from severely disabled persons with equal aptitude and qualifications will be given preference. Women are strongly encouraged to apply. Applicants with a degree that was not obtained at a German higher education institution must submit a Statement of Comparability for Foreign Higher Education Qualifications from the Central Office for Foreign Education (https://www.kmk.org/zab/central-office-for-for-eign-education) as proof of equivalence. The Statement of Comparability can be issued after offering the position.

If you have any questions, please contact Dr. Mohamed Nagia, phone: 0345 55-25952, e-mail: .

Please send your application stating the reg. no. 5-5815/24-D as one PDF document with a letter of motivation, CV, copies of diplomas and contact details of two references by 28.10.2024 to Martin Luther University Halle- Wittenberg, Dr. Mohamed Nagia, Tel.: 0345 55-25952, E-Mail: . Incomplete applications will not be considered.